Distinguished Scientist - Immunotoxicology

Job description

Job Overview

With the Sanofi portfolio evolving to include more biological and immunomodulatory modalities in the Oncology and Immunology and Inflammation therapeutic areas, there is an increasing need to address safety issues related to the immune system. The successful candidate will report to the Global Head of Investigative Toxicology and be the point-of-contact for immunotoxicology in the global Preclinical Safety group at Sanofi. This role will be responsible for devising and executing plans to address immune-related safety issues at all stages in development, with specific focus prior to drug candidate nomination and selection. The candidate will work collaboratively with colleagues across Sanofi sites worldwide to drive the development of immunotoxicology models both in-house and with external vendors, and support application of these models within the Sanofi portfolio. Participation in external immunotoxicology consortia and representing Sanofi at relevant scientific venues is also a component of this role.

Responsibilities

·  Serve as the global leader and point-of-contact in Preclinical Safety for immunotoxicology and immune-related safety issues.
·  Support the development of strategies to manage safety risks for immunomodulatory candidates in collaboration with Sanofi subject matter experts and Preclinical Safety project team members.
·  Design mechanistic experiments and coordinate supporting Investigative Toxicology resources to address immune-related safety issues. The Author reports supporting inclusion of results in white papers or regulatory submissions as needed.
·  Oversee and drive the development of necessary assays and tools for assessing the impact on immune function and application of these assays and tools for both screening compounds for safety liabilities and investigation of mechanisms of toxicity. Ensure scientific rigor, including designing appropriate validation plans and testing strategies. Promote and support the use of these models by project teams.
·  Direct and oversee incorporation of immune components in vitro microphysiological system models, including strategy for evaluation and qualification.
·  Review and/or author immunotoxicology sections of regulatory submission documents and provide subject matter expertise for addressing regulatory queries and concerns.
·  Participate in external immunotoxicology consortia and symposia to keep current with industry trends and regulatory evolution in the immunotoxicology field. Represent Sanofi interests, maintaining high ethical and scientific standards. Author external presentations and manuscripts to contribute to the scientific advancement of the immunotoxicology field.

Requirements & Qualifications

PhD in immunology, toxicology, pharmacology, biology, or equivalent scientific discipline required, with a minimum of 15 years of experience in the pharmaceutical or biotechnology industry. Knowledge and expertise in immunology and immunological assays is required. Experience in the field of toxicology and regulatory safety requirements is also necessary. Experience working with biological modalities is a plus. Established record of scientific contribution in peer-reviewed journals and scientific symposiums. Excellent verbal and written communication skills.

Terms of Employment

Occasional domestic and international travel to Sanofi Research and Development sites and scientific meetings. Availability to start in 4Q2019.

What makes this position unique?

The candidate will be part of a growing Investigative Toxicology group at Sanofi and have the opportunity to help shape and guide research in the immunotoxicology field. This is an excellent opportunity for career growth and leadership in the exciting, expanding field of immunotoxicology, and the global scope will provide the candidate with rich, diverse work experience.

Benefits of working in this role

The candidate will

·  Be part of an active, innovative scientific group
·  Demonstrate leadership and subject matter expertise in immunotoxicology
·  Have diverse opportunities to collaborate globally
·  Be highly recognized for successes
·  Receive excellent benefits and compensation

Location information

The position is based in Framingham, MA.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.