Offers “Roche”

Expires soon Roche

Research Associate RNA Mechanisms/Neural Signalling in Neuroscience & Rare Diseases Research

  • Internship
  • Basel, SWITZERLAND
  • Personal services

Job description



·  Job facts

At Roche, we believe it is urgent to deliver medical solutions now – even as we develop innovations for the future. We are passionate about improving the lives of patients with brain diseases, and strive for ambitious ideas, innovative approaches and urgent action. Our belief is that our success as a company will come from developing therapies for patients in need, which is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

Within Roche's Pharma Research and Early Development (pRED), Neuroscience & Rare Diseases represents a major focus area where we are committed to realizing our long-term vision of changing lives of patients with severe brain disorders. Our preclinical research and early clinical development activities center around large and rare indications within the four major pillars of neurodevelopmental disorders, movement disorders, dementias, and multiple sclerosis. With unparalleled strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science to medicines for patients with disorders of the nervous system.

To achieve our goals, Roche pRED Neuroscience & Rare Diseases is currently undergoing a major and exciting recruitment effort for a large number of new positions including a Research Associate in Neural Signalling/RNA Mechanisms in the Section of Neural Signalling within the Department of Neuroscience & Rare Diseases Research. All positions are based in Basel, Switzerland.

The position

As Research Associate you will support with your expertise in cellular and molecular biology the RNA mechanisms lab within the Neural Signalling Section and broadly projects on RNA biology. In our highly collaborative and multidisciplinary pharma research environment you will perform exploratory activities in RNA biology with respect to Neuroscience & Rare Diseases indications of interest and provide project support for assay development, understanding disease mechanisms, and establishing screens.

Your main responsibilities

·  You will support the RNA mechanisms, the Neural Signalling section and the broader department as the technical expert on using molecular biology tools to investigate RNA mechanisms in Neuroscience and Rare Disease Therapeutics.
·  You will provide technical leadership for the lab and section in these areas and also proactively suggest future scientific avenues.
·  You will also join a vibrant multicultural team of scientists, associates, postdocs and students working towards innovative approaches to drug discovery in CNS disorders.

Who we are

At Roche, 98,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer.

Desired profile

Who you are

Must haves

·  You are a Master's graduate in cellular and molecular biology and have a minimum of 2 years of lab experience; having a background in Neuroscience is a plus
·  You have deep technical expertise in cellular and molecular biology such as high quality RNA extraction for RNA sequencing, designing primer probe sets and developing multiplexed real time PCR assays with the Taqman platform.
·  You have experience in basic cell biology techniques including immunofluorescence and confocal microscopy imaging.
·  You have experience with in vitro systems such as various cell lines with developing assays. You are passionate about Neuroscience and rare disease drug discovery and bring a flexible mindset to an agile department with fast-paced project work.
·  You are able to follow and present relevant scientific publications and extract and establish methodology from papers in your own research.
·  You are well self-organized and driven and have excellent communication skills in English and are good at planning, recording, executing experiments and data analysis. You have a solid understanding of basic statistics and feel comfortable in applying statistical tools beyond Excel (eg Graph Pad Prism, Fireplex).
·  You have strong interpersonal soft skills to lead collaborative research work in a multi-disciplinary matrix structure.

Desirable haves

·  Experience with next generation sequencing technologies is aplus. Experience with oligonucleotide and CRISPR techniques to elucidate pathways and mechanisms in a cell biology context is a plus.
·  Experience with high content image analysis on the confocal microscope or another system such as Operetta is a plus.
·  Know-how in iPSC or stem-cell applications is a plus.
·  Experience in programming in R or Python are a plus

Are you ready to apply? Roche embraces diversity and equal opportunity in a serious way. We are committed to building teams that represents a range of backgrounds, perspectives, and skills.

If you still have questions then please check our FAQs and videos on careers.roche.ch/faq.

Please note that applications for Research Associate positions by PhD graduates and postdocs will not be considered.

For non-EU / EFTA citizens: Please state your eligibility status to work in Switzerland (e.g. B-Permit, C-Permit) and note that if you do not own a valid Swiss work permit, Roche cannot guarantee your final employment due to authority regulations.

Roche is an equal opportunity employer.
Research & Development, Research & Development > Research

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