Post Doctorate Scientist in T Cell Bispecific antibodies (2 years)

Job description

  Job facts

Who we are (Global):
At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity, and on seeing each other's differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing – and is seeking people who have the same goals for themselves.
At Roche, we believe it's urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients' lives and we are fearless in both decision and action. And we believe that good business means a better world.
That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

Who we are (local):
The Roche Innovation Center Zurich (RICZ) is active in the research and development of engineered therapeutic antibodies, with a focus in cancer biology and cancer immunotherapy. Part of the Roche Group since 2005, it employs about 180 people.

The Position:
You will join research teams based at Roche Innovation Center Zürich (Schlieren, Switzerland) and will focus on the study of T Cell Bispecific antibodies (TCBs). Your main tasks will be to perform in vivo, ex vivo and in vitro studies dedicated to deeper characterization of different aspects of TCB mode of action.

The principal responsibilities will include:
• Design and conduct in vivo animal studies to answer key open questions related to TCB mode of action
• Conduct ex vivo analyses of tumors, blood and additional organs derived from in vivo animal studies using multiparametric flow cytometry and/or CyTOF
• Conduct ex vivo functional assays using Tumor Infiltrating Lymphocytes (TILs) or splenocytes to characterize the functionality of T cells and other immune cells in the tumor microenvironment
• Contribute to activities applying high dimensional single cell analysis approaches for deeper molecular characterization of tumors (including single cell RNA sequencing and CyTOF)
• Data analysis and interpretation, preparation of scientific presentations, regular presentations at internal and external meetings
• Writing of scientific reports and research articles

Who you are:
You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies, and where a job title is not considered the final definition of who you are, but the starting point.
We are searching for a highly motivated Scientist to join our Cancer Immunotherapy research and development unit. You are someone with excellent scientific and organizational skills, dedicated working attitude, fully committed to team work and highly flexible.

For this position you bring the following qualifications:
• PhD in cancer immunotherapy, tumor immunology or cell biology (previous experience with T Cell Bispecific antibodies is a plus)
• Sound knowledge and experience of conducting in vivo animal studies, including animal handling, injections, surgery and blood/organ isolation
• Excellent hands-on experience with ex vivo organ isolation and processing and analysis of the same using multiparametric flow cytometry (previous experience with CyTOF is a plus)
• Excellent hands-on experience with ex vivo assessment of immune cell functionality including assessment of immune cell activation, cytokine production (intracellular and secreted). Previous experience in T cell
exhaustion is a plus.
• Strong communication, interpersonal, and organizational skills, excellent teammate
• A high degree of self-motivation, flexibility and capacity to independently setup and conduct experiments, ability to take initiative and work according to time-lines
• Interest on working in a multidisciplinary and multinational environment

When does it start? The Postdoc Fellowship can start according to the arrangement as soon as possible and latest in December 2019. Please clearly indicate your preferred starting date on your motivation letter. All applications always need to include a CV and a motivation letter.

Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq

Tags: ROiBT, ROiDS, RoiMB, ROiBY, ROiLS

·  Who we are

The Roche Innovation Center Zurich (Roche Glycart AG) is active in the research and development of engineered therapeutic antibodies, with a focus on the fields of cancer immunotherapy. Part of the Roche Group since 2005, it currently employs about 140 people. Read more .

Roche is an equal opportunity employer.

Desired profile

Who you are:
You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies, and where a job title is not considered the final definition of who you are, but the starting point.
We are searching for a highly motivated Scientist to join our Cancer Immunotherapy research and development unit. You are someone with excellent scientific and organizational skills, dedicated working attitude, fully committed to team work and highly flexible.

For this position you bring the following qualifications:
• PhD in cancer immunotherapy, tumor immunology or cell biology (previous experience with T Cell Bispecific antibodies is a plus)
• Sound knowledge and experience of conducting in vivo animal studies, including animal handling, injections, surgery and blood/organ isolation
• Excellent hands-on experience with ex vivo organ isolation and processing and analysis of the same using multiparametric flow cytometry (previous experience with CyTOF is a plus)
• Excellent hands-on experience with ex vivo assessment of immune cell functionality including assessment of immune cell activation, cytokine production (intracellular and secreted). Previous experience in T cell
exhaustion is a plus.
• Strong communication, interpersonal, and organizational skills, excellent teammate
• A high degree of self-motivation, flexibility and capacity to independently setup and conduct experiments, ability to take initiative and work according to time-lines
• Interest on working in a multidisciplinary and multinational environment

When does it start? The Postdoc Fellowship can start according to the arrangement as soon as possible and latest in December 2019. Please clearly indicate your preferred starting date on your motivation letter. All applications always need to include a CV and a motivation letter.

Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq

Tags: ROiBT, ROiDS, RoiMB, ROiBY, ROiLS

·