Post-doctorat en bioinformatique structurale
Internship FRANCE IT development
Job description
Détail de l'offre
Informations générales
Entité de rattachement
Le Commissariat à l'énergie atomique et aux énergies alternatives (CEA) est un organisme public de recherche.Acteur majeur de la recherche, du développement et de l'innovation, le CEA intervient dans le cadre de ses quatre missions :
. la défense et la sécurité
. l'énergie nucléaire (fission et fusion)
. la recherche technologique pour l'industrie
. la recherche fondamentale (sciences de la matière et sciences de la vie).
Avec ses 16000 salariés -techniciens, ingénieurs, chercheurs, et personnel en soutien à la recherche- le CEA participe à de nombreux projets de collaboration aux côtés de ses partenaires académiques et industriels.
Référence
2019-10801Description de la Direction
Genoscope is at the forefront of large-scale sequence-based science. Today, our institute performs biological and bioengineering research with applications in environment, healthcare and alternative energy. The Genoscope encompasses multidisciplinary team of ~100 staff with postdocs and engineers having expertise in genomics, bioinformatics, microbiology, biochemistry and biocatalysis.
Description de l'unité
The successful candidate will be a key member of a research project, MODAMDH, funded by the French Research Agency (ANR) and carried out in the Research Unit of Genoscope (CEA, CNRS, Paris-Saclay Univ., UMR8030).
The MODAMDH project aims at finding new amine dehydrogenases among biodiversity. It will be carried out by innovative approaches based on distant homology and 3D modeling of enzymes to mine massive (meta)genomic data. This project involved the biocatalysis (LBMS) and bioinformatics (LABGeM) teams of the Genoscope in collaboration with the York Structural Biology Laboratory (York, UK).
Description du poste
Domaine
Biologie, biophysique et biochimie
Contrat
CDD
Intitulé de l'offre
Post-doctorat en bioinformatique structurale
Statut du poste
Cadre
Durée du contrat (en mois)
24
Description de l'offre
The candidate will be in charge of conducting bioinformatics analysis using cutting-edge methods in structural bioinformatics and sequence analysis. Large amount of candidate enzymes will be experimentally screened and selected hits will be characterized for biocatalysis application by a PhD student involved in this project. In addition, structural determination of the enzymes will be performed with another PhD student of the York laboratory.
Location: France > Evry (91000)> Genoscope
Pour plus de détails, merci de consulter le site web https://bit.ly/2Zs2QEG
Desired profile
Profil du candidat
- PhD degree in bioinformatics or structural biology (a first experience in molecular modeling is essential)
- Technical skills:
Molecular modeling (ab initio/homology modeling, ligand docking, structural motifs)
Analysis of massive (meta)genomics data sets (comparative and functional genomics)
Programming skills and High-Throughput Computing
- Employability skills: strong communication and organizational skills, ability to work in a team-oriented environment, autonomy, good english skills are required and notions of french would be a plus.